李冠楠

1985年生，讲师，遗传学专业，主讲西南大学A类课程《智慧农业》。曾获得中国精品科技期刊顶尖学术论文领跑者5000（F5000）荣誉证书，并指导西南大学本科生参加“大学生创新创业大赛”，其中项目《微生态菌剂饲料对家蚕的益生功效机理研究》获得重庆市级奖项。以第一作者发表SCI论文12篇（其中中科院一区论文3篇、二区论文6篇），曾主持或参与国家级和省部级项目10余项以上，目前在研校级项目1项，已获得国家授权发明专利1项。现担任英文科技期刊《iMeta》《Food Science of Animal Products》和《Agriculture Communications》等青年编委，同时担任中文核心期刊《食品研究与开发》《食品发酵工业》等特邀审稿人，并为《Microbiome》《Journal of Advanced Research》《Scientific Reports》《BMC Genomics》《BMC Microbiology》《Archives of Microbiology》《FEMS Microbiology Letters》及《Journal of Polymers and the Environment》等SCI期刊审稿人。研究方向：当前主要从事家蚕毒理学、益生菌-昆虫宿主互作和可食用昆虫开发应用等方面研究。具体：1.家蚕为模式生物探究兼性次级共生体对宿主生长发育和营养代谢的作用机理；2.研究有毒物质对家蚕肠内稳态、免疫扰动和血液循环代谢物的损害机制；3.可食用昆虫食品的营养功效。

一、教育及工作经历

教育经历

2005.09-2009.06 西南大学 生物工程 本科

2010.09-2016.06 西南大学 遗传学     博士

工作经历

2016-2017 上海市农业科学研究院 助理研究员

2017-2020 西南大学                         博士后

2019-2020 新加坡国立大学             博士后

2022-至今 西南大学                         讲师

二、代表性科研成果

1.代表性科研项目

(1)国家自然科学基金项目，《家蚕肠道微生物戊糖片球菌Pediococcus pentosaceus参与宿主抵御病原细菌感染的机制研究》,50万元，2025-2028，主要成员（排名第二）。

(2)西南大学大学生创新创业训练计划项目，《微生态菌剂饲料对家蚕的益生功效机理研究》，2024-2025，指导教师。

(3)中央高校基本科研业务费，《家蚕益生菌筛选及其功能研究》， 20万元，2023-2025，在研，主持。

(4)重庆市博士后国际学术交流计划，（International Conference on Agriculture and Biotechnology），3万元，已结题，主持。

(5)重庆市博士后特别资助项目，《家蚕细菌病的生物防治策略研究》，（Xm2017177），5万元，2018-2020，已结题，主持。

(6)西南大学中央高校基本科研业务费专项资金，《蚕用益生菌的分离筛选及其益生作用研究》，1万元,2014-2015，已结题，主持.

(7)国家自然基金地区基金，《噬菌体尾部蛋白协同突变的重获侵染能力机制研究》，,35万元，已结题，2022-2025，主要成员（排名第二）.

(8)国家自然基金地区基金，《家蚕肠源阴沟肠杆菌对肠道微环境影响及免疫互作机制研究》，,35万元，2022-2025，参与.

(9)Impact of okara on gut health in Singapore middle-aged and older adults, Ministry of Education (R-160-000-A44-114), Singapore. 6万新币，参与

(10)国家农业科技成果转化资金，《高抗氟性家蚕新品种“渝蚕2号”的推广与示范》，（2012GB2F100376），60万元，已结题，参与

(11)重庆市重大科技攻关项目，《多元化蚕桑实用技术研发》，(CSTC,2009AA1024)，100万元，已结题，参与

(12)贵阳市科技基金项目，《昆虫致病菌逃逸机制研究》，（筑科合同[2017]30-1），8 万元，参与。

2.代表性科研论文

(1)Li G.N., Song Y.Z., Xiao Y., et al. Biological effects of viable and nonviable Bacillus subtilis on the microbiota-gut-blood system through the modulation of gut microbiota and circulating metabolites. Journal of Future Foods 2026. (IF2024=5.2, 中科院一区)

(2)Li G.N., Zheng X., Zhu Y., et al. In-depth insights into the disruption of the microbiota-gut-blood barrier of hosts by fluoride. Science of The Total Environment. 2022, 838: 156220. (IF2021=10.753; 中科院一区)

(3)Li G.N., Shi M., Zhao S., et al. Toxicity response of silkworm intestine to Bacillus cereus SW7-1 pathogen. Science of the Total Environment. 2019, 692: 1282-1290. (IF2019=6.551；中科院一区)

(4)Li G.N., Wu M.H., Xiao Y., et al. Multi-omics reveals the ecological and biological functions of Enterococcus mundtii in the intestine of lepidopteran insects. Comp Biochem Physiol Part D Genomics Proteomics 2024, 52: 101309. (IF2024=2.2；中科院二区).

(5)Xia X.J., Lu J., Chen X.Y., Zhou L., Huang Y.D., Ding S.J., Li G.N. Impact of whole grain highland hull-less barley on the denaturing gradient gel electrophoresis profiles of gut microbial communities in rats fed high-fat diets. Microbiology Spectrum. 2024, 12(6): e0408923. (IF2024=3.7；中科院二区，唯一通讯作者)

(6)Li G.N., Tong Y.J., Xiao Y., et al. Probiotic Bacillus subtilis contributes to the modulation of gut microbiota and blood metabolic profile of hosts. Comp Biochem Physiol C Toxicol Pharmacol. 2023; 272:109712. (IF2023=3.9；中科院二区)

(7)Li G.N., Zheng X., Zhu Y., et al. Bacillus symbiont drives alterations in intestinal microbiota and circulating metabolites of lepidopteran host. Environmental Microbiology. 2022; 24: 4049-4064. (IF2021=5.476；中科院二区)

(8)Li G.N., Xia X.J., Zhao S., et al. The physiological and toxicological effects of antibiotics on an interspecies insect model. Chemosphere. 2020, 248: 126019. (IF2020=7.086；中科院二区)

(9)Li G.N., Xia X.J., Zhao H.H., et al. Intestinal microecology associated with fluoride resistance capability of the silkworm (Bombyx mori L.). Applied Microbiology and Biotechnology. 2016, 100(15): 6715-6724. (IF2016=3.420；中科院二区)

(10)Li G.N., Xiao Y., Leng J., et al. Beneficial efficacy and mode of action of probiotic Bacillus subtilis SWL−19 on the silkworm (Bombyx mori L.). Symbiosis. 2024, //doi.org/10.1007/s13199-024-00986-4. (IF2023=2.5；中科院三区)

(11)Li G.N., Cai M., Zheng X., et al. Impact of disinfectants on the intestinal bacterial symbionts and immunity of silkworm (Bombyx mori). Environmental Science and Pollution Research. 2022; 29:79545-79554. (IF2021=5.190, 中科院三区)

(12)Li G.N., Shi M., Zhao S., et al. RNA-Seq comparative analysis reveals the response mechanism of Enterococcus faecalis TV4 under fluoride exposure. GENE. 2020, 726: 144197. (IF2020=3.688；中科院三区)

(13)Li G.N., Xia X.J., Zhao H.H., et al. Identification and characterization of Bacillus cereus SW7-1 in Bombyx mori (Lepidoptera: Bombycidae). Journal of Insect Science. 2015, 15(1): 136-140. (IF2015=0.650；中科院三区)

(14)Zhao T.F., Wu M.H., Li C.H., Li G.N. Nutritional value and future potential of edible insects in food systems. Food Science and Animal Products. 3 (2025) 9240130. //doi.org/10.26599/FSAP.2025.9240130. (通讯作者)

(15)Xia XJ, Li GN, Xing YX, et al. Antioxidant activity of whole grain highland hull-less barley and its effect on liver protein expression profiles in rats fed with high-fat diets. European Journal of Nutrition, 2017, 57: 2201-2208. (共同一作；IF2017=4.423；中科院二区)

(16)SENDEGYA P., Li G.N., Zhao H.H., et al. Effect of fluoride on the midgut proteins of T6 and 734 strains of the silkworm (Bombyx mori). Fluoride. 2016, 49(2):102-111. (共同一作；IF2015=1.342；中科院四区)

(17)Xia, X., Li, G.N., Dong, Q.L., et al. Endothelial progenitor cells as an emerging cardiovascular risk factor in the field of food and nutrition research: advances and challenges. Crit Rev Food Sci Nutr. 2023, 21:1-18. (IF2022=10.2; 中科院一区)

(18)Xia X.J., Li G.N., Ding Y.B., Ren T.Y., Zheng J., Kan J.Q.* Effect of whole grain Qingke (Tibetan Hordeum vulgare L. Zangqing 320) on serum lipid levels and intestinal microbiota of rats under high-fat diet. Journal of Agricultural and Food Chemistry. 2017, 65(13): 2686-2693. (IF2015= 2.857; 中科院一区)

(19)Xia XJ, Li G.N., Song JX, et al. Hypocholesterolaemic effect of whole-grain highland hull-less barley in rats fed a high-fat diet. British Journal of Nutrition, 2018, 119: 1102-1110. (IF2017=3.706；中科院二区)

(20)Xia X.J., Li G.N., Zheng J., Wu J.S., Kan J.Q. Immune activity of sweet potato (Ipomoea batatas L.) glycoprotein after enzymatic and chemical modifications. Food & Function. 2015, 6(6): 2026-202. (IF2015=2.686；中科院一区)

(21)Xia X.J., Xing Y.X., Li G.N., et al. Antioxidant activity of whole grain Qingke (Tibetan Hordeum vulgare L.) toward oxidative stress in D-galactose induced mouse model. Journal of Functional Foods. 2018, 45: 355-362. (IF2018=3.197；中科院大类二区)

(22)Xia X.J., Li G.N., Zheng J., Ran C.X., Kan J.Q. Biochemical, textural and microstructural changes in whole-soya bean cotyledon sufu during fermentation. International Journal of Food Science and Technology. 2014, 49(8): 1834-1841. (IF2014=1.504；中科院大类二区)

(23)Xia X.J., Li G.N., Liao F.R., et al. Granular structure and physicochemical properties of starches from amaranth grain. International Journal of Food Properties. 2015, 18(5): 1029-1037. (IF2015=1.586；中科院大类四区)

(24)Tang WC, Xiao YY, Li G.N., et al. Analysis of digital gene expression profiling in the gonad of male silkworms (Bombyx mori) under fluoride stress. Ecotoxicology and Environmental Safety. 2018, 153: 127-134. (IF2018=4.527；中科院一区)

(25)Long Y.H., Li J.R., Zhao T.F., Li G.N., Zhu Y. A new arylalkylamine N-acetyltransferase in silkworm (Bombyx mori) affects integument pigmentation. Applied Biochemistry and Biotechnology. 2015, 175(7): 3447-3457. (IF2015=1.606；中科院四区)

(26)Hu W.Z., Zhou S.X., Ibrahim A., Li G.N., Awad S., Ramos-Vivas J., Kan J.Q., Du M.Y. Whole genome analysis of Pediococcus acidilactici XJ-24 and is role in preventing Listeria monocytogenes ATCC® 19115TM infection in C57BL/6 mice. Antibiotics. 2025, 14(3):323. (IF2024=4.6；中科院二区)

(27)Zheng X., Liu F.D., Shi M., Li S., Xie X.F., Li G.N., Zhang X.N., Zhu Y. Transcriptome analysis of the reproduction of silkworm (Bombyx mori) under dimethoate stress. Pesticide Biochemistry and Physiology. 2022, 183: 105081. (IF2021=3.963；中科院一区)

(28)夏雪娟，陈莉敏，李冠楠. 乳杆菌对肠内分泌细胞胰高血糖素样肽3331分泌的影响. 食品发酵与工业. 2024,50(7):17-25. (《中国科技期刊卓越行动计划入选项目》重点期刊；通讯作者)

(29)李冠楠，夏雪娟，SENDEGYA Parfait等. 蚕用益生芽孢杆菌SWL-19的筛选鉴定及其对肠道菌群多样性的影响. 中国农业科学. 2015, 48(9): 1845-1853.

(30)李冠楠，夏雪娟，SENDEGYA Parfait等. 氟化物对家蚕肠道微生物菌群的影响. 微生物学报. 2015, 55(7): 926-934.

(31)李冠楠，夏雪娟，隆耀航等. 抗菌肽的研究进展及其应用. 动物营养学报. 2014, 26(1): 17-25.

(32)李冠楠，夏雪娟，赵欢欢等. 氟化物对家蚕耐氟和氟敏品种肠道中留存产酶菌群落组成和多样性的影响. 昆虫学报. 2014, 57(2): 187-193.

(33)石敏，李冠楠，郑茜等. 乐果对家蚕生殖腺及氧化应激反应的影响. 昆虫学报. 2019, 62(10): 1186-1196.

(34)夏雪娟，李冠楠，廖丽婷等. 基于Miseq测序技术分析高脂膳食对不同性别SD大鼠盲肠菌群的影响. 中国食品学报. 2019, 19(01): 223-232.

(35)何石宝，李冠楠，郭东东等. 果蝇求偶行为分子调控机制的研究进展. 中国生物工程杂志. 2015， 35(10): 78-85.

(36)阚建全，夏雪娟，李冠楠等. 加工处理对甘薯糖蛋白免疫调节和降胆固醇功能的影响. 食品科学. 2015, 36(7): 194-199.

(37)米智，阮成龙，李冠楠等. 家蚕氟中毒后中肠NADPH-细胞色素P450还原酶和NADPH-细胞色素C还原酶活性的变化. 蚕业科学. 2012, 38(1): 0102-0108.

3.发明专利

(1)朱勇*，李冠楠等，《蚕用益生枯草芽孢杆菌SWL-19及其应用》.2018-02-06,中国发明专利, ZL 201510119974.6.

三、联系方式

邮箱：g[email protected]

电话：19123024503