周游

博士，副教授，硕士生导师。问鼎娱乐 生物技术系主任，西塔问鼎 生物技术（中外合作办学）专业负责人。主持并完成国家自然科学基金青年基金项目、重庆市基础研究与前沿探索项目、重庆市留学人员创新创业支持计划等多项研究课题。受邀担任Bioorganic & Medicinal Chemistry Letters、Molecules、Pharmaceuticals等学术杂志审稿人。目前主要围绕桑树活性物质开展小分子药物研发与作用机制研究。研究领域：主要围绕桑树活性物质开展小分子药物研发与作用机制研究。

一、教育及工作经历

教育经历

2002.09-2006.06 第三军医大学                        药学             本科

2006.09-2009.06 郑州大学                               药物化学      硕士

2009.09-2013.06 中国药科大学             药物化学      博士

工作经历

2013-2021 问鼎娱乐-问鼎官网       讲师

2021-至今 问鼎娱乐-问鼎官网       副教授

二、代表性科研成果

1. 代表性科研项目

（1）国家自然科学基金青年基金：新型BuChE-IDO1双靶标抑制剂的设计、合成及其抗阿尔茨海默症活性研究

（2）重庆市科委基础研究与前沿探索项目：新型BuChE-IDO1双靶标抑制剂的构效关系、结合模式及其抗AD活性研究

2. 代表性科研论文

（1）Junwei Chen, Zhonglang Gou, Guoxin Yang, Lingli Zhou, An Na Kim, Wenchao Shi, You Zhou*. Ferroptosis, a Distinct Form of Cell Death, and Research Progress on Its Modulators. Pharmaceuticals, 2025, 18(12):1785.

（2）Junwei Chen, Zhonglang Gou, Yufei Huang, Qianhui Yu, An Na Kim, Wenchao Shi, You Zhou*. Research Progress on Phytochemicals from Mulberry with Neuroprotective Effects: A Review. Pharmaceuticals, 2025, 18(5):695.

（3）You Zhou*, Xin Lu, Chenxi Du, et al. Novel BuChE-IDO1 inhibitors from sertaconazole: Virtual screening, chemical optimization and molecular modeling studies. Bioorganic & Medicinal Chemistry Letters, 2021, 34:127756.

（4）Xin Lu, Yijun Liu, Nan Qin, Hongyu Yang, Yuting Qiao, Xueyang Jiang, Yao Chen, Feng Feng, Wenyuan Liu, You Zhou*, Haopeng Sun*. Synthesis and activity of miconazole derivatives as dual BChE-IDO1 inhibitors for the treatment of Alzheimer's disease. Future Medicinal Chemistry, 2020, 13:1105-1125.

（5）You Zhou*, Yanyu Hu, Xin Lu, et al. Discovery of a Selective 6-Hydroxy-1,4-Diazepan-2-one Containing Butyrylcholinesterase Inhibitor by Virtual Screening and MM-GBSA Rescoring. Dose-Response, 2020, 18.

（6）You Zhou*, Xin Lu, Hongyu Yang, et al. Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations. Molecules, 2019, 24:4217–4231.

（7）Xin Lu, Siyu He, Qi Li, Hongyu Yang, Xueyang Jiang, Hongzhi Lin, Yao Chen,Wei Qu, Feng Feng, Yaoyao Bian, You Zhou*, Haopeng Sun*. Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer’s disease. Bioorganic & Medicinal Chemistry, 2018, 26:1665-1674.

（8）You Zhou, Xiaoli Xu, Yuan Sun, Huaping Wang, Haopeng Sun*, Qidong You*. Synthesis, cytotoxicity and topoisomerase II inhibitory activity of lomefloxacin derivatives. Bioorganic & Medicinal Chemistry Letters, 2013, 23(10):2974-8.

3.发明专利

（1）周游,勾中浪,史文超,等. 一种天然产物Moracin N的合成方法:CN202410778796.7[P].CN118772094A[2026-03-06].

（2）周游,赵宏旭,王煜晨,等. 一类具有呋喃并[3,2-g]色烯结构的化合物及其应用:CN202511784570.9[P].CN121318993A[2026-03-06]

三、联系方式

邮箱：[email protected]